Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC).
Identifieur interne : 000028 ( Main/Exploration ); précédent : 000027; suivant : 000029Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC).
Auteurs : Brenda M. Birmann [États-Unis] ; Gabriella Andreotti [États-Unis] ; Anneclaire J. De Roos [États-Unis] ; Nicola J. Camp [États-Unis] ; Brian C H. Chiu [États-Unis] ; John J. Spinelli [Canada] ; Nikolaus Becker [Allemagne] ; Véronique Benhaim-Luzon [France] ; Parveen Bhatti [États-Unis] ; Paolo Boffetta [États-Unis] ; Paul Brennan [France] ; Elizabeth E. Brown [États-Unis] ; Pierluigi Cocco [Italie] ; Laura Costas [Espagne] ; Wendy Cozen [États-Unis] ; Silvia De Sanjosé [Espagne] ; Lenka Foretová [République tchèque] ; Graham G. Giles [Australie] ; Marc Maynadié [France] ; Kirsten Moysich [États-Unis] ; Alexandra Nieters [Allemagne] ; Anthony Staines [Irlande (pays)] ; Guido Tricot [États-Unis] ; Dennis Weisenburger [États-Unis] ; Yawei Zhang [États-Unis] ; Dalsu Baris [États-Unis] ; Mark P. Purdue [États-Unis]Source :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1538-7755 ] ; 2017.
Abstract
Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI.Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls.Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m(2) increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14; P = 0.007]. We observed significant heterogeneity by study design (P = 0.04), noting the BMI-multiple myeloma association only for population-based studies (Ptrend = 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m(2); OR, 1.2; 95% CI, 1.1-1.3; P = 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (Pinteraction <0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25-<30 kg/m(2)) or obese (30+ kg/m(2)) in both younger and usual adulthood (vs. individuals consistently <25 kg/m(2)), but not for those overweight or obese at only one time period.Conclusions: BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood.Impact: These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention. Cancer Epidemiol Biomarkers Prev; 26(6); 876-85. ©2017 AACR.
DOI: 10.1158/1055-9965.EPI-16-0762-T
PubMed: 28223430
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Irlande (pays), Italie, République tchèque, États-Unis
- Alabama, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Bourgogne, Bourgogne-Franche-Comté, Californie, Catalogne, Connecticut, District de Fribourg-en-Brisgau, District de Karlsruhe, Illinois, Iowa, Maryland, Massachusetts, Moravie, Pennsylvanie, Rhône-Alpes, Utah, Washington (État), État de New York
- Barcelone, Brno, Dijon, Fribourg-en-Brisgau, Heidelberg, Lyon
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Birmann</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. brenda.birmann@channing.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J" last="De Roos">Anneclaire J. De Roos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J" last="Camp">Nicola J. Camp</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Chiu, Brian C H" sort="Chiu, Brian C H" uniqKey="Chiu B" first="Brian C H" last="Chiu">Brian C H. Chiu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Studies, University of Chicago, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Health Studies, University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Control Research, BC Cancer Agency and School of Population and Public Health, University of British Columbia, Vancouver, British Coulmbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Control Research, BC Cancer Agency and School of Population and Public Health, University of British Columbia, Vancouver, British Coulmbia</wicri:regionArea><wicri:noRegion>British Coulmbia</wicri:noRegion></affiliation></author><author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name><affiliation wicri:level="3"><nlm:affiliation>German Cancer Center, Division of Cancer Epidemiology, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Center, Division of Cancer Epidemiology, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Benhaim Luzon, Veronique" sort="Benhaim Luzon, Veronique" uniqKey="Benhaim Luzon V" first="Véronique" last="Benhaim-Luzon">Véronique Benhaim-Luzon</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bhatti, Parveen" sort="Bhatti, Parveen" uniqKey="Bhatti P" first="Parveen" last="Bhatti">Parveen Bhatti</name><affiliation wicri:level="2"><nlm:affiliation>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation wicri:level="2"><nlm:affiliation>Mount Sinai School of Medicine, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Mount Sinai School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Brown, Elizabeth E" sort="Brown, Elizabeth E" uniqKey="Brown E" first="Elizabeth E" last="Brown">Elizabeth E. Brown</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and the Cancer Control and Population Sciences Program, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Department of Pathology and the Cancer Control and Population Sciences Program, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Costas, Laura" sort="Costas, Laura" uniqKey="Costas L" first="Laura" last="Costas">Laura Costas</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretová">Lenka Foretová</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name><affiliation wicri:level="3"><nlm:affiliation>Registry of Hematological malignancies of Côte d'Or, University of Burgundy, and University Hospital, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Registry of Hematological malignancies of Côte d'Or, University of Burgundy, and University Hospital, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Moysich, Kirsten" sort="Moysich, Kirsten" uniqKey="Moysich K" first="Kirsten" last="Moysich">Kirsten Moysich</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name><affiliation wicri:level="3"><nlm:affiliation>Center for Chronic Immunodeficiency, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Chronic Immunodeficiency, Faculty of Medicine, University of Freiburg, Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name><affiliation wicri:level="1"><nlm:affiliation>Ireland School of Nursing and Human Sciences, Dublin City University, Glasnevin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Ireland School of Nursing and Human Sciences, Dublin City University, Glasnevin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Tricot, Guido" sort="Tricot, Guido" uniqKey="Tricot G" first="Guido" last="Tricot">Guido Tricot</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Iowa, Iowa City, Iowa.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Internal Medicine, University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Weisenburger, Dennis" sort="Weisenburger, Dennis" uniqKey="Weisenburger D" first="Dennis" last="Weisenburger">Dennis Weisenburger</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, City of Hope, Duarte, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, City of Hope, Duarte</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Yale School of Medicine, New Haven, Connecticut.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Surgery, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Baris, Dalsu" sort="Baris, Dalsu" uniqKey="Baris D" first="Dalsu" last="Baris">Dalsu Baris</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P" last="Purdue">Mark P. Purdue</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28223430</idno><idno type="pmid">28223430</idno><idno type="doi">10.1158/1055-9965.EPI-16-0762-T</idno><idno type="wicri:Area/PubMed/Corpus">000A71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A71</idno><idno type="wicri:Area/PubMed/Curation">000A68</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A68</idno><idno type="wicri:Area/PubMed/Checkpoint">000A68</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A68</idno><idno type="wicri:Area/Ncbi/Merge">004351</idno><idno type="wicri:Area/Ncbi/Curation">004351</idno><idno type="wicri:Area/Ncbi/Checkpoint">004351</idno><idno type="wicri:Area/Main/Merge">000023</idno><idno type="wicri:Area/Main/Curation">000028</idno><idno type="wicri:Area/Main/Exploration">000028</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC).</title><author><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M" last="Birmann">Brenda M. Birmann</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. brenda.birmann@channing.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J" last="De Roos">Anneclaire J. De Roos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J" last="Camp">Nicola J. Camp</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Division of Hematology and Hematologic Malignancies, University of Utah School of Medicine, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Chiu, Brian C H" sort="Chiu, Brian C H" uniqKey="Chiu B" first="Brian C H" last="Chiu">Brian C H. Chiu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Studies, University of Chicago, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Health Studies, University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Control Research, BC Cancer Agency and School of Population and Public Health, University of British Columbia, Vancouver, British Coulmbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Control Research, BC Cancer Agency and School of Population and Public Health, University of British Columbia, Vancouver, British Coulmbia</wicri:regionArea><wicri:noRegion>British Coulmbia</wicri:noRegion></affiliation></author><author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name><affiliation wicri:level="3"><nlm:affiliation>German Cancer Center, Division of Cancer Epidemiology, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Center, Division of Cancer Epidemiology, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Benhaim Luzon, Veronique" sort="Benhaim Luzon, Veronique" uniqKey="Benhaim Luzon V" first="Véronique" last="Benhaim-Luzon">Véronique Benhaim-Luzon</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bhatti, Parveen" sort="Bhatti, Parveen" uniqKey="Bhatti P" first="Parveen" last="Bhatti">Parveen Bhatti</name><affiliation wicri:level="2"><nlm:affiliation>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation wicri:level="2"><nlm:affiliation>Mount Sinai School of Medicine, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Mount Sinai School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Brown, Elizabeth E" sort="Brown, Elizabeth E" uniqKey="Brown E" first="Elizabeth E" last="Brown">Elizabeth E. Brown</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and the Cancer Control and Population Sciences Program, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Department of Pathology and the Cancer Control and Population Sciences Program, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Costas, Laura" sort="Costas, Laura" uniqKey="Costas L" first="Laura" last="Costas">Laura Costas</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretová">Lenka Foretová</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name><affiliation wicri:level="3"><nlm:affiliation>Registry of Hematological malignancies of Côte d'Or, University of Burgundy, and University Hospital, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Registry of Hematological malignancies of Côte d'Or, University of Burgundy, and University Hospital, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Moysich, Kirsten" sort="Moysich, Kirsten" uniqKey="Moysich K" first="Kirsten" last="Moysich">Kirsten Moysich</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name><affiliation wicri:level="3"><nlm:affiliation>Center for Chronic Immunodeficiency, Faculty of Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Chronic Immunodeficiency, Faculty of Medicine, University of Freiburg, Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name><affiliation wicri:level="1"><nlm:affiliation>Ireland School of Nursing and Human Sciences, Dublin City University, Glasnevin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Ireland School of Nursing and Human Sciences, Dublin City University, Glasnevin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Tricot, Guido" sort="Tricot, Guido" uniqKey="Tricot G" first="Guido" last="Tricot">Guido Tricot</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Iowa, Iowa City, Iowa.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Internal Medicine, University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Weisenburger, Dennis" sort="Weisenburger, Dennis" uniqKey="Weisenburger D" first="Dennis" last="Weisenburger">Dennis Weisenburger</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, City of Hope, Duarte, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, City of Hope, Duarte</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Yale School of Medicine, New Haven, Connecticut.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Surgery, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Baris, Dalsu" sort="Baris, Dalsu" uniqKey="Baris D" first="Dalsu" last="Baris">Dalsu Baris</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P" last="Purdue">Mark P. Purdue</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville</wicri:cityArea></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="eISSN">1538-7755</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI.Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls.Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m(2) increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14; P = 0.007]. We observed significant heterogeneity by study design (P = 0.04), noting the BMI-multiple myeloma association only for population-based studies (Ptrend = 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m(2); OR, 1.2; 95% CI, 1.1-1.3; P = 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (Pinteraction <0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25-<30 kg/m(2)) or obese (30+ kg/m(2)) in both younger and usual adulthood (vs. individuals consistently <25 kg/m(2)), but not for those overweight or obese at only one time period.Conclusions: BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood.Impact: These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention. Cancer Epidemiol Biomarkers Prev; 26(6); 876-85. ©2017 AACR.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Alabama</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Californie</li><li>Catalogne</li><li>Connecticut</li><li>District de Fribourg-en-Brisgau</li><li>District de Karlsruhe</li><li>Illinois</li><li>Iowa</li><li>Maryland</li><li>Massachusetts</li><li>Moravie</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Utah</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Brno</li><li>Dijon</li><li>Fribourg-en-Brisgau</li><li>Heidelberg</li><li>Lyon</li></settlement></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M" last="Birmann">Brenda M. Birmann</name></region><name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name><name sortKey="Baris, Dalsu" sort="Baris, Dalsu" uniqKey="Baris D" first="Dalsu" last="Baris">Dalsu Baris</name><name sortKey="Bhatti, Parveen" sort="Bhatti, Parveen" uniqKey="Bhatti P" first="Parveen" last="Bhatti">Parveen Bhatti</name><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><name sortKey="Brown, Elizabeth E" sort="Brown, Elizabeth E" uniqKey="Brown E" first="Elizabeth E" last="Brown">Elizabeth E. Brown</name><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J" last="Camp">Nicola J. Camp</name><name sortKey="Chiu, Brian C H" sort="Chiu, Brian C H" uniqKey="Chiu B" first="Brian C H" last="Chiu">Brian C H. Chiu</name><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J" last="De Roos">Anneclaire J. De Roos</name><name sortKey="Moysich, Kirsten" sort="Moysich, Kirsten" uniqKey="Moysich K" first="Kirsten" last="Moysich">Kirsten Moysich</name><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P" last="Purdue">Mark P. Purdue</name><name sortKey="Tricot, Guido" sort="Tricot, Guido" uniqKey="Tricot G" first="Guido" last="Tricot">Guido Tricot</name><name sortKey="Weisenburger, Dennis" sort="Weisenburger, Dennis" uniqKey="Weisenburger D" first="Dennis" last="Weisenburger">Dennis Weisenburger</name><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name></country><country name="Canada"><noRegion><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name></region><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Benhaim Luzon, Veronique" sort="Benhaim Luzon, Veronique" uniqKey="Benhaim Luzon V" first="Véronique" last="Benhaim-Luzon">Véronique Benhaim-Luzon</name></region><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name></country><country name="Italie"><noRegion><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Costas, Laura" sort="Costas, Laura" uniqKey="Costas L" first="Laura" last="Costas">Laura Costas</name></region><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjosé">Silvia De Sanjosé</name></country><country name="République tchèque"><region name="Moravie"><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretová">Lenka Foretová</name></region></country><country name="Australie"><noRegion><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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